Research insights from ultra-rapid whole genome sequencing are being used at California’s largest children’s hospital to improve care of critically-ill newborns
MOUNTAIN VIEW, Calif.–(BUSINESS WIRE)–DNAnexus, the global leader in genome informatics and data management, announced that Rady Children’s Institute for Genomic Medicine (RCIGM) in San Diego has adopted the DNAnexus Platform to enable the world’s fastest whole genome data analysis pipeline for pediatric care settings. The work is part of a National Institute of Health (NIH) research program led by Stephen Kingsmore, MD, DSc, President and CEO of RCIGM.
RCIGM plans to expand this integrated solution to partners nationally, fostering a growing genomic database that healthcare providers can access to quickly diagnose rare disease in children.
DNAnexus is facilitating this goal by providing a flexible and scalable platform for local and distributed sequencing and analysis and enabling a highly optimized end-to-end rapid whole genome solution. At RCIGM, the platform is also being used to securely bank genomic data, work with collaborators and integrate with the Institute’s custom portal and big-data platform.
The Institute’s integrated process spans genomic phenotyping through to interpretation of results and allows for data aggregation and synthesis to improve diagnosis, semi-automate reporting and to establish metrics for diagnostic and clinical utility.
“Our goal is to ensure that genome-powered precision medicine is available to every child who needs it. To do this, building a research-to-bedside pipeline at a single hospital isn’t enough. We needed a solution that can be scaled up and is accessible anywhere in the world,” said Dr. Kingsmore. “DNAnexus has the technology and expertise to facilitate this ambitious project, allowing us to collaborate in a secure environment.”
The NIH Newborn Sequencing In Genomic Medicine and Public Health program addresses how genomic sequencing can replicate or augment known screening results for newborn disorders, what knowledge sequencing can provide for conditions not currently screened, and what additional information could be learned from sequencing relevant to the clinical care of newborns. The NSIGHT program is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Human Genome Research Institute components of the National Institutes of Health.
“Rady Children’s Institute for Genomic Medicine is a pioneer in the use of genomic data to drive better outcomes for children with inherited diseases, and we are proud to support this cutting-edge work led by Dr. Kingsmore,” said Richard Daly, CEO of DNAnexus. “DNAnexus serves as a secure and compliant network supporting multiple locations and enabling providers such as Rady with the technical platform to expand their network and data analysis capacity globally and in a cost-effective manner.”
About Rady Children’s Institute for Genomic Medicine
The Institute is leading the way in advancing precision pediatric medicine by combining ultra-rapid whole genome sequencing with expert analysis and interpretation to speed diagnosis of genetic disease. Research conducted at RCIGM is being used to improve care of critically ill newborns at Rady Children’s Hospital-San Diego. Learn more at www.RadyGenomics.org
About Rady Children’s Hospital-San Diego
Rady Children’s Hospital-San Diego is a 551-bed pediatric care facility providing the largest source of comprehensive pediatric medical services in San Diego, Southern Riverside and Imperial counties. Rady Children’s is the only hospital in the San Diego area dedicated exclusively to pediatric healthcare and is the region’s only designated pediatric trauma center. In June 2016, U.S. News & World Report ranked Rady Children’s among the best children’s hospitals in the nation in nine pediatric specialties the magazine surveyed. Rady Children’s is a nonprofit organization that relies on donations to support its mission. For more information, visit www.rchsd.org and find us on Facebook, Twitter and Vimeo.
About DNAnexus
DNAnexus combines expertise in computing and bioinformatics to create the global network for genomics, operating in North America, Europe, Asia-Pacific (including China), South America, and Africa. The secure, scalable, and collaborative DNAnexus Platform helps thousands of researchers across a spectrum of industries – biopharmaceutical, bioagricultural, sequencing services, clinical diagnostics, government, and research consortia – accelerate their genomics programs globally. For more information on DNAnexus, please visit www.dnanexus.com or follow the company @DNAnexus.
Contacts
for DNAnexus
Colin Sanford, 415-946-1094
csanford@purecomunications.com