PD-L1 IHC 28-8 pharmDx Will Give More Insight to Which Patients with Urothelial Cancer are Most Likely to Benefit from Opdivo (nivolumab)
SANTA CLARA, Calif., June 16, 2017
Agilent Technologies Inc. (NYSE: A) today announced expanded access to a clinically validated test for PD-L1 (programmed death-ligand 1), that will help physicians in Europe make more informed decisions about how best to treat patients with Urothelial Cancer (UC).
Europe is the first region to launch a PD-L1 CE-IVD test for UC globally. The CE marking demonstrates the product meets all relevant European Medical Device Directives. The PD-L1 IHC 28-8 pharmDx has broad utility as it has already been previously CE marked for detecting tumor cell PD-L1 expression for non-squamous, non-small-cell lung cancer, squamous cell carcinoma of head and neck and melanoma. PD-L1 IHC 28-8 pharmDx now has more clinically validated tissue indications than any other commercially manufactured PD-L1 assay on the market.
Opdivo (nivolumab), an immunotherapy developed by Bristol-Myers Squibb, is indicated for the treatment of previously treated locally advanced unresectable or metastatic UC in adults after failure of prior platinum-containing therapy regardless of PD-L1 status. Data from a recent clinical study CA209275 (Checkmate 275), showed that tumor PD-L1 expression assessed by PD-L1 IHC 28-8 pharmDx may help inform which UC patients are more likely to respond to Opdivo.
Because individual patients may respond differently to the same treatment, scientists have been focusing development of personalized medicine, which is where Agilent’s Dako brand of diagnostics comes into play, providing important information about the status of key biomarkers in individual cancer patients.
Agilent is a worldwide leader in partnering with pharmaceutical companies to develop immunohistochemical-based diagnostics for cancer therapy.
Expanded use in other countries is currently pending approval.
About Agilent Technologies
Agilent Technologies Inc. (NYSE: A), is a global leader in analytical laboratory technologies. With more than 50 years of insight and innovation, our instruments, software, services, solutions and people provide trusted answers to our customers’ most challenging questions. The company generated revenues of $4.20 billion in fiscal 2016 and employs about 13,000 people worldwide. In 2012, Agilent acquired Dako, a well-known provider of reagents, instruments, software and expertise to make accurate diagnoses and determine the most effective treatment for cancer patients. Information about Agilent is available here, and information about Dako is available here.
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Contact:
Victoria Wadsworth-Hansen
Agilent Technologies
+1 408-553-2005
+45 29336980
victoria.wadsworth-hansen@agilent.com
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