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Leica’s HyVolution solution transforms a confocal microscope into a super-resolution microscope. Teaming ingenious inventions with smart implementation has resulted in a confocal microscope with continuously tunable filter functions, the Leica TCS SP8. It seamlessly adapts to any dye or dye combination you may want to employ. As a second pillar, the tunable elements provide maximal transmission. This prevents loss of your precious emission, whilst enabling very thin sectioning conditions. After all, optical sectioning is the main reason for buying a confocal microscope.
Compare the results: 3 channel simultaneous acquisition of COS7 cells with HyVolution super-resolved (right) versus confocal (left). Green: Mitochondria (Oregon Green 488), red: Actin (SiR), white: Tubulin (TMR). Sample courtesy of Dr. Jana Doehner, Center of Microscopy and Image Analysis, University of Zurich, Switzerland.
High sensitivity and thin optical sections then merge with scientific image reconstitution to result in super-resolved images with high contrast and very low noise. That is exactly what you need.
HyVolution does not overload the optical beam path with additional elements, no fibers are required to transmit the emission and no optics are needed to adapt the diffraction pattern. All channels can operate in parallel in super-resolution mode, at all magnifications and wavelengths independently, including UV– and IR-excitation. And it is available for non-descanning detector signals too.
If you want to image living samples speed is what matters. The Leica TCS SP8 offers truly parallel channel recording, ensuring no decrease in imaging speed, whatever configuration you choose.
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