BOSTON, June 3, 2019 — 908 Devices, a pioneer of analytical devices for chemical and biomolecular analysis, today announced several advancements to their ZipChip® product line, which build upon its industry-leading biotherapeutic analysis capabilities in multiple critical application areas. These product and application expansions will be showcased at the 67th Annual ASMS Conference being held in Atlanta, Georgia, June 2 – 6, in booth #802.
Two consumable enhancements dubbed BOOST and SHIFT improve sensitivity and enable native protein analysis on a broader range of Thermo Fisher Scientific mass spectrometers. BOOST gives researchers 20X greater sensitivity when performing native intact protein analysis, revealing detail that was previously unresolvable. SHIFT brings native analysis to mass spectrometers with limited high-mass sensitivity. This now allows biopharmaceutical scientists to run native CE-MS (capillary electrophoresis – mass spectrometry) assays on their existing, non-extended-mass range instrumentation without a hardware upgrade.
With continued focus on reducing complexity for customers, the company has announced the public Beta release of DARWIN, an automated software solution to expedite the analysis of ZipChip and MS data of proteins and biotherapeutics. Exclusively available to ZipChip users, DARWIN eliminates most of the manual choices, selections, and decisions encumbering typical analysis software, and directly reports identified species, modifications and relative abundances. Customers will be able to preview DARWIN at the ASMS Conference.
The company also announced compatibility of their ZipChip platform with a wider range of High-Resolution Accurate Mass (HRAM) instrument manufacturers.
ZipChip compatibility now expands to a broader set of SCIEX mass spectrometers to include SCIEX TOF instruments in addition to Triple Quad and QTRAP® series systems.
908 Devices and Bruker have also entered into a collaboration agreement to integrate ZipChip onto Bruker mass spectrometers. This collaboration is specifically aligned to bring fast and simple ZipChip CE separations to the Bruker line of TOF instruments including the timsTOF Pro and MaXis systems for the characterization of Critical Quality Attributes (CQAs) in the biotherapeutics space.
These newly compatible devices are expected to be available as early as Q4 this year.
Throughout the ASMS conference the power and utility of ZipChip will be showcased in the works of many scientists, including those from Regeneron Pharmaceuticals, The National Institute for Bioprocessing Research & Training Dublin, Bristol-Myers Squibb, University of Kentucky Lexington, Duke University School of Medicine Durham, Corteva Agriscience, University of Texas at Austin, and UNC Chapel Hill. A breadth of applications ranging from intact protein determination to high-throughput native charge variant analysis will be presented.